Isotechnika Pharma Develops Portfolio of Non-Immunosuppressive Cyclosporine Analogue Molecules (NICAMs)

Isotechnika Pharma Inc. (TSX: ISA) today announced that it has developed a portfolio of non- immunosuppressive cyclosporine analogue molecules (NICAMs) with potent cyclophilin inhibition. Cyclophilin inhibition has garnered considerable attention as a novel therapy in the treatment of a wide range of diseases including hepatitis C, stroke, and chronic neurological disorders such as Parkinson's, Lou Gehrig's, and Alzheimer's. Cyclosporine A is a well established cyclophilin inhibitor, however, its additional strong binding to calcineurin results in powerful immunosuppression and limits its therapeutic potential to transplantation and various autoimmune disorders. NICAMs do not bind to calcineurin yet retain the ability to inhibit cyclophilin.